Risk of Acute Kidney Injury Following Mytomicin C Resorption during Hyperthermic Intraperitoneal Chemotherapy

Background: Surgical cytoreduction and simultaneous hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is a common treatment for peritoneal carcinomatosis. During chemotherapy, mitomycin C frequently used. Mitomycin known to be nephrotoxic. Little about the effect of systemically absorbed on renal function during HIPEC surgery. Methods: In twenty-two patients undergoing cytoreductive surgery carcinomatosis systemic levels were measured in plasma. The relation plasma with duration complexity was evaluated. Furthermore, we evaluated between function. Results Two total 22 developed acute kidney injury. these patients, preoperative creatinine level increased from (1) 109 μmol/L maximum 890 6th postoperative day after which replacement therapy started (2) 67 213 μmol/L. Whereas 2 145 μg/L 280 compared other (167 ±80.8). Peak post operative 2. None needed therapy. Eight showed significant increase levels, i.e. >20% values. We did not observe correlation surgery, absorption C, higher signs Conclusions: Systemic independent extension this small study group, observed an impairment may related C. Further research warranted answer possible association at risk development AKI.